devenez membre de l'AFMF
Vous êtes ici :Accueil du site > La maladie > La Génétique et les modes de transmission

La Génétique et les modes de transmission

C’est une maladie génétique transmise selon le mode récessif (sauf pour les très rares patients du groupe B) et très hétérogène : 13 gènes ont été identifiés jusqu’à présent. Le rôle des protéines correspondantes est encore mal connu.

Ces gènes sont appelés FANCA, FANCB, FANCC, FANCD1 (également connu sous le nom BRCA2 ce gène est impliqué dans les cancers du sein familiaux), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM et FANCN. Ils sont tous portés par des chromosomes autosomes, sauf le gène FANCB qui est porté par le chromosome X, expliquant pourquoi les patients de ce groupe sont tous des garçons ; c’est le seul groupe pour lequel la transmission est liée au sexe.

Le gène le plus souvent en cause est le gène FANCA impliqué chez deux-tiers des patients. Des mutations de FANCA, FANCC, FANCG ou FANCD2 sont retrouvées chez plus de 90% des patients. Les autres gènes sont très rarement en cause avec pour certains d’entre eux moins de 5 malades connus.

irbesartan price walmart more avanafil china amitriptyline tablets rapamune purchase online buy caverta 50 mg revlimid sales tenofovir cost uk http://www.phaseivengr.com/order-clarithromycin.pdf $4 bupropion in mexico memantine kopen http://artistlane.com/ciprofloxacin-hcl-250-mg.pdf lasix 50mg http://www.naturaldiamondcompany.com/comprar-poxet.pdf info about lipitor online pharmacy otc pepcid mg in uk http://pulseseismic.com/buy-paxil-30-mg.pdf nexium discount in california http://upsizemag.com/diovan-160mg.pdf glipizide er drug buy amitryn http://www.phaseivengr.com/revlimid-drug.pdf amoxicillin drug buy gleevec imatinib buy protonix lioresal baklofen order amantadine risperidone price furosemide 40mg 232;me-kopen.pdf malegra fxt in india http://artistlane.com/cost-of-fosamax.pdf abilify russian in united states http://upsizemag.com/letrozole-purchase.pdf viread oral generic warfarin generic flonida http://pulseseismic.com/lenalidomide-price.pdf dexamethasone pill buy generic paxil mobic 7.5 tab purchase spironolactone usa information about generic pioglitazone from india http://www.phaseivengr.com/buy-generic-amisulpride-online.pdf maxalt mlt generic in india celecoxib online in france amoxicillin capsules cheapest cymbalta 20 mg buy valif usa isotretinoin price without insurance in usa buying in mexico lenalidomide latanoprost cost in usa lamisil product kamagra oral jelly 100mg more mobic meloxicam 15mg arcalion med generic levitra with dapoxetine in california http://www.phaseivengr.com/irovel-tablets.pdfbuy finpecia online uk 20 mg enalapril rapamune tab more simvastatin pfizer 10mg modafinil buy clozaril more info bactrim medicine organon sustanon 50mg buspirone buspar buy promethazine cough syrup megalis tablets in hindi lipitor online pharmacy dapoxetine price in mumbai orlistat 60 mg bupropion 12 sr benicar hct prices in california generic melanocyl calutide for sale buy baclof 25mg in usa fluconazole tablets in india info about trazodone 150mg bactrim for boils furosemide tab 40mg betnovate c cream http://www.phaseivengr.com/nolvadex-online-paypal.pdf acyclovir 400 mg in usa buy furosemide online otc amoxicillin info about flagyl generic terbinafine no prescription information about buy bupropion xl online prevacid solutab coupon in usa order nexium in france gleevec tab remeron sol tab info about geftinat tablets more griseofulvin ultra 250 mg http://upsizemag.com/amisulpride-online.pdf drug risperdal in uk buy cheap ketasma buy bicalutamide online in usa more info about acyclovir 800mg more buy iressa gefitinib http://upsizemag.com/pricing-for-bimatoprost-ophthalmic-solution-0-03.pdf information calaptin 40 mg drug diovan hct 12.5mg http://artistlane.com/price-generic-fluvoxamine.pdf information zocor 40 mg tablet benicar on line xenical malaysia progesterone purpose http://www.naturaldiamondcompany.com/tab-nizonide-500.pdf buy cardura avodart drug quetiapine 200 mg buy stendra online http://artistlane.com/fluorouracil-cream-price.pdf erlonat suppliers caberlin online in mexico http://www.phaseivengr.com/rizatriptan-cost-walgreens.pdf nitazoxanide order diflucan 100 mlbuy super p force 100mg vilitra 20mg info about tadacip 20mg buy tadaga 40mg sildigra information buy sildisoft viraday 300mg buy tadasoft 20mg buy vidalista 20mg tadasoft 40mg more buy snovitra 20mg tadasoft 20mg buy suhagra in usa caverta 100mg info about buy suhagra 100mg buy tadaga in uk suhagra 100mg tadaga 40mg in usa buy vidalista in california buy tadasoft http://www.puptection.com/component/k2/item/164/ http://www.puptection.com/blog/alkaline-diet/ buy tadasoft 40mg more info about buy sildisoft 50mg vidalista 20mg buy snovitra Buy cenforce in france buy tadacip super p force 100mg snovitra 20mg information about buy tadacip 20mgpromethazine 12.5 tablets snovitra xl dapoxetine australia buy super p force with mastercard dulcolax tablets vilitra online amiloride 10 mg flomax 180 capsules ampicillin english more linezolid price in pakistan http://dumbbellbombshell.com/cost-for-doxycycline http://maxmyshopping.com/wp/generic-for-zestril generic caberlin information doxycycline 100 by mail careprost cost http://howtogrowcreativechildren.com/imatinib-generic cost of prevacid more info about maleato de enalapril viread xenical online pricing for bimatoprost ophthalmic solution 0.03 250mg levaquin terbinafine cream for sale http://internationalfundinggroup.com/vasotec-medicinenet http://foolatics.co.uk/femara-for-sale-uk information about suhagra cipla order sildigra bactrim 960 mg nexium generic https://silverstatedrivingacademy.com/blog/ciprofloxacin-hcl-500-mg-taran valtrex cheap erlotinib price buspirone forms letrozole indi more info about tadacip buy valsartan costo tadaga 60 mg inderal 40 mg fluoxetine hcl 20mg cap amitriptyline 10mg buy generic azithrocin http://americanautodistributing.com/buy-nodict a-ret information about anastrozole cost without insurance more esomeprazole oral more armodafinil purchase http://wisdomofthetoga.com/mobic-15-mg-tabletki viread in india more info buying metronidazole information about depo medrol 80mg avodart cap in usa diovan price comparison http://wokingham-berks.com/purchase-floricot femara manufacturer bupropion hcl xl cymbalta generic equivalent fincar tablets http://edcharkow.com/blog/imatinib-gleevec zoloft mg